By F. Lang, M. Ritter, H. Völkl, D. Häussinger (auth.), Prof. Dr. Florian Lang, Prof. Dr. Dieter Häussinger (eds.)
One of the necessities for survival is the power of cells to take care of their quantity. hence, through the process evolution cells have "learned" quite a few options to accomplish quantity homeostasis. This quantity regulatory equipment comprises legislation of either, mobile metabolism and mobile delivery and is exploited by way of hormones and transmitters to manage cellularfunction. This booklet to illustrates the advanced interaction of phone quantity regulatory mechanisms and mobile functionality in a number of tissues. even if, our wisdom remains to be faraway from being conclusive, and the current selection of reports is assumed to foster additional experimental efforts to solve the function of telephone quantity within the built-in functionality of cells.
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Extra info for Advances in Comparative and Environmental Physiology: Interaction of Cell Volume and Cell Function
Volume- and timedependent activation and inactivation of ion transport pathways. J Gen Physiol 83: 513-527 Cell Volume Regulatory Mechanisms - An Overview 29 Sarkadi B, Cheung R, Mack E, Grinstein S, Gelfand EW, Rothstein A (1985) Cation and anion transport pathways in volume regulatory response of human lymphocytes to hyposmotic media. Am J Physiol 248: C480-C487 Schild L, Aronson PS, Giebisch G (1991) Basolateral transport pathways for K+ and Clin rabbit proximal tubule: effects on cell volume.
Accordingly, physiological fluctuations of the portal amino acid concentration are accompanied by parallel alterations of liver cell volume. The degree of amino acid-induced cell swelling seems to be largely related to the steady-state intra/extracellular amino acid concentration gradient. This gradient and, accordingly, the degree of cell swelling are modified by hormones and the nutritional state in a complex way. Their action not only involves effects on the expression of plasma membrane transport systems and the electrochemical Na + gradient as a driving force for Na + -coupled transport, but also alterations of intracellular amino acid metabolism.
J Membr Bioi 102: 121-130 Lewis SA, Butt AG, Bowler MJ, Leader JP, Macknight ADC (1985) Effects of anions on cellular volume and transepithelial Na+ transport across toad urinary bladder. J Membr Bioi 83: 119-137 Lifschitz MD (1986) Prostaglandins may mediate chloride concentration gradient across domes formed by MDCKI cells. Am J Physiol 250: F525-F531 Linshaw MA (1980) Effect of metabolic inhibitors on renal tubule cell volume. Am J Physiol 239: F571-F577 Linshaw MA, Grantham 11 (1980) Effect of collagenase and ouabain on renal cell volume in hypotonic media.
Advances in Comparative and Environmental Physiology: Interaction of Cell Volume and Cell Function by F. Lang, M. Ritter, H. Völkl, D. Häussinger (auth.), Prof. Dr. Florian Lang, Prof. Dr. Dieter Häussinger (eds.)