By Dale J. Benos (Eds.)
Sodium reabsorbing epithelia play an incredible function in whole-body sodium homeostasis. a few examples of sodium regulating tissues contain kidney, colon, lung, and sweat ducts. Sodium shipping throughout those membranes is a two-step procedure: access via an amiloride-sensitive sodium channel and go out through the ouabain-sensitive sodium/potassium ATPase. The sodium access channels are the rate-limiting determinant for delivery and are regulated by means of a number of assorted hormones. The sodium channels additionally play an important function in a couple of sickness states, like high blood pressure, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: body structure and useful variety offers the 1st in-depth alternate of principles relating those sodium channels, their rules and involvement in common and pathophysiological events. Key gains * Summarizes present kingdom of amiloride-sensitive sodium channel box * Analyzes structure-function of epithelial sodium channels * Discusses immunolocalization of epithelial sodium channels * Examines hormonal legislation of sodium channels * Discusses sodium channels in lymphocytes, kidney, and lung * Considers mechanosensitivity of sodium channels * presents rules on sodium channels and illness
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Additional resources for Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity
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Sci. 83,2767-2770. Palmer, L. , and Frindt, G. (1986b). Epithelial sodium channels: Characterization by using the patch-clamp technique. Fed. , Fed. Am. Exp. Biol. 45,2708-2712. Perez, G . , Adelman, J. , and Toro, L. (1994). Reconstitution of expressed Kc, channels from Xenopus oocytes to lipid bilayers. Biophys. J. 66, 1022-1027. , and Papazian, D. M. (1994). S4 mutations alter gating currents of Shaker K channels. Biophys. J. 66, 345-354. Prat, A. , Bertorello, A. , Ausiello, D. , and Cantiello, H.
J. Physiol. 269, C641-C654. Fuller, C. , Ismailov, I. , Berdiev, B. , Shlyonsky, V. , and Benos, D. J. (1996). Kinetic interconversion of rat and bovine homologs of the ct subunit of an amiloride-sensitive Na' channel by C-terminal truncation of the bovine subunit. J. Biol. Chem. 271,26602-26608. Fuller, C. , Berdiev, B. , Shlyonsky, V. , Ismailov, I. , and Benos, D. J. (1997). Point mutations in abENaC regulate channel gating, ion selectivity and sensitivity to amiloride. Biophys. J. 72, 1622-1632.
Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity by Dale J. Benos (Eds.)