Anti-Idiotypes, Receptors, and Molecular Mimicry - download pdf or read online

By D. Scott Linthicum, Nadir R. Farid

ISBN-10: 1461237343

ISBN-13: 9781461237341

ISBN-10: 1461283256

ISBN-13: 9781461283256

Here is an updated evaluation of significant new tools and leads to anti-idiotypes, receptors, and molecular mimicry.It starts off with a dialogue of the theoretical historical past ofthe anti-idiotypic community, it is function within the law of immune reaction, and the actual features of anti-idiotypic antibodies. It then is going directly to discover many exciting purposes in such parts as insulin motion, thyroid cellphone functionality, the neurosciences, cardiology, virology, pharmacology, and copy.

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Extra resources for Anti-Idiotypes, Receptors, and Molecular Mimicry

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1) (0) or the outer cavity sites (A and B in Fig. 4. 1) (0 ) . 9 was determined by competitive EIA and compared to the competitive binding of noncomplexed Mcg (D). 30 Robert L. Raison and Allen B. B. , unpublished work). After prolonged incubation with hapten, the complex was dialyzed to remove bis(DNP)lysine from the main cavity. The ligand in the deep pocket remained firmly bound. 0 mole of bis(DNP)lysine per mole of Mcg dimer, as determined by absorbance at 365 nm. This preparation showed a markedly reduced ability to bind the M3.

158: 1769. 12. A. Boux. 1985. Conformation dependence ofa monoclonal antibody defined epitope on free human kappa chains. Mol. Immunol. 22: 1393. 13. R. Ely, P. A. J. B. Edmundson. 1978. Interconversion of conformational isomers of light chains in the Mcg immunoglobulins. Biochemistry 17: 148. 14. L. R. B. Edmundson. 1973. 5-A. resolution. Biochemistry 12:4620. 15. R. E. Abola, M. Schiffer, and N. Panagiotopoulos. 1975. Rotational allomerism and divergent evolution of domains in immunoglobulin light chains.

C. Ellory. and G. Dawson. 1983. Molecular size of opiate (enkephalin) receptors in neuroblastoma-glioma hybrid cells as determined by radiation inactivation analysis. J. BioI. Chern. 258:2101. II. • S. L. M. J. Simon. 1985. Covalent labeling of opioid receptors with radioiodinated human b-endorphin. J. BioI. Chern. 260: 10833. 12. F. W. R. E. c. Rice. 1982. Identification of aM, 58000 glycoprotein subunit of the opiate receptor. FEBS Lett. 150: 125. 13. D. D. L. E. Blalock. 1986. Antibodies to the binding site of the LHRH receptor: generation with a synthetic decapeptide encoded by a RNA complementary to LHRH mRNA.

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Anti-Idiotypes, Receptors, and Molecular Mimicry by D. Scott Linthicum, Nadir R. Farid


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